In Matthew 10, Jesus instructs his disciples to go out and spread his teachings. He gives them the authority to heal the sick and cast out demons. Jesus warns them that they will face persecution, but reassures them that God will be with them. He advises them to be wise and cautious, to rely on God's providence, and to share the good news without fear. Jesus emphasizes the importance of loyalty and declares that those who welcome his disciples will also welcome him, and ultimately God.